Keyword "DYSFUNCTION" found in the following publications:

• CARDIOVASCULAR EFFECTS OF AN ARGINASE II SELECTIVE INHIBITOR

  For the first time in vitro experiments there were studied the inhibitory activity and safety of potential molecules arginase II ...

  Abstract | Full text (PDF)

• MODERN POSSIBILITIES OF USING THE RELEASE-ACTIVE DRUG TENOTEN FOR CHILDREN IN THE CLINICAL PRACTICE OF AUTONOMIC DISORDERS IN CHILDREN
   

  Background: Among the pathological conditions found in children and adolescents, vegetative disorders occupy one of the leading places. ...

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• CONCOMITANT USE OF STATINS AND S-(2-BORON-ETHYL)-L-CYSTEINE ARGINASE INHIBITOR TO CORRECT ENDOTOXIN-INDUCED ENDOTHELIAL DYSFUNCTION

  The concomitant use of non-selective S-(2-boron-ethyl)-L-cysteine (BEC) arginase inhibitor with simvastatin, atorvastatin, rosuvastatin and nanoparticulated rosuvastatin on the background of ...

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• PHARMACOLOGICAL EFFICACY OF AN INHIBITOR OF ARGINASE-2 KUD975 WITH L-NAME-INDUCED ENDOTHELIAL DYSFUNCTION

  The study of endotelio- and cardioprotective activity of finished dosage forms - tablets, film-coated, containing 10 mg of phenolic ...

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• USE OF L-ARGININE IMMOBILISED ON ACTIVATED CARBON FOR PHARMACOLOGICAL CORRECTION OF ENDOTHELIAL DISFUNCTION

  For the first time a complex of L-arginine sodium salt of sulfate of cellulose acetate on activated carbon. To investigate ...

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• PHARMACOLOGICAL EFFICIENCY OF STATINS AND L-NORVALIN AT AN ENDOTOXIN-INDUCED ENDOTHELIAL DYSFUNCTION

  In the animals with endotoxin-induced endothelial dysfunction there were imbalance of contractile response of vessels wall observes when carrying out ...

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• PHARMACOLOGICAL CORRECTION OF L-NAME-INDUCED OXIDE DEFICIENCY WITH DERIVATIVES OF 3-(2,2,2- TRIMETHYLHYDRAZINIUM) PROPIONATE

  This paper deals with the study of correction of L-NAME-induced endothelial dysfunction by means of 3-(2,2,2-trimethylhydrazinium) propionate derivatives. We have ...

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• CHANGES IN THE RESPIRATORY FUNCTION OF THE HEART AND BRAIN MITOCHONDRIA OF ANIMALS AFTER CHRONIC ALCOHOL INTOXICATION AFFECTED BY A NEW GABA DERIVATIVE

  Introduction: Chronic ethanol consumption leads to significant functional and structural changes in the mitochondria of the heart and ...

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• LONG-TERM EFFECTS AND DEVELOPMENT OF PSYCHOSEXUALITY IN PEOPLE – VICTIMS OF SEXUAL ABUSE

  Background: Numerous studies show the disorganizing effect of sexual abuse in childhood and adolescence in all areas of ...

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• THE STUDY OF OSTEOPROTECTIVE PROPERTIES OF NANOPARTICULATED FORMS OF RESVERATROL AND LOSARTAN

  The study demonstrated that endothelial dysfunction of bone microvasculature and deterioration of regional blood flow in bone developed eight weeks ...

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• PHARMACOLOGICAL CORRECTION OF ENDOTHELIAL DYSFUNCTION USING ADEMETHIONIN AND TAURINE

  Introduction: Рharmacological correction of endothelial dysfunction is a urgent problem of modern medicine.

  Materials and methods: Endothelial dysfunction was simulated ...

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• ENDOTHELIO-AND CARDIOPROTECTIVE EFFECTS OF HMG-CO-A REDUCTASE IN ENDOTOKSIN-INDUCING ENDOTELIAL DYSFUNCTION

  The use of inhibitors of HMG-Co-A reductase inhibitor Simvastatin, Atorvastatin, Rosuvastatin and nanoparticulated Rosuvastatin on the background modeling of endotoxin-induced ...

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• CORRECTION OF MORPHOFUNCTIONAL DISORDERS OF THE CARDIOVASCULAR SYSTEM WITH ASIALIZED ERYTHROPOIETIN AND ARGINASE II SELECTIVE INHIBITORS KUD 974 AND KUD 259 IN EXPERIMENTAL PREECLAMPSIA
  
   

  Introduction: Preeclampsia remains one of the most common causes of maternal and perinatal mortality worldwide. A significant role in the ...

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• ENDOTHELIUM AND CARDIOPROTECTIVE EFFECTS OF HMG-CO-A-REDUCTASE IN COMBINATION WITH L-ARGININE IN ENDOTHELIAL DYSFUNCTION MODELING

  Abstract. Using the combined application of L-arginine with HMG-Co-A reductase inhibitors simvastatin, atorvastatin, rosuvastatin and nanoparticulated rosuvastatin on the background ...

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• ENDOTHELOTROPIC ACTIVITY OF 4-HYDROXY-3,5-DI-TRET-BUTYLCINNAMIC ACID IN THE CONDITIONS OF EXPERIMENTAL CEREBRAL ISCHEMIA

  Introduction: The aim of the study was to evaluate the endothelioprotective activity of 4-hydroxy-3,5-di-tret-butylcinnamic acid in conditions of experimental ...

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• PHARMACOTHERAPEUTIC STRATEGIES FOR ENDOTHELIAL DYSFUNCTION CORRECTION WITH USE OF STATINES IN SYNDROME OF SYSTEMIC INFLAMMATORY RESPONSE

  Objectives: The ways of pharmacological correction of cardiovascular complications in the syndrome of the systemic inflammatory response (SIRS) are ...

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• THE MAIN DIRECTIONS FOR PHARMACOLOGICAL CORRECTION (COMBINATIONS OF DRUGS FOR GENERAL ANESTHESIA) OF NEUROLOGICAL AND COGNITIVE DISORDERS IN PATIENTS WITH NEOPLASMS OF THE CENTRAL NERVOUS SYSTEM

  Introduction: the problem of neuroprotective or neurodegenerative effects of drugs for general anesthesia is relevant in connection with a ...

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• STUDY OF THE MICROCIRCULATION LEVEL IN BONE WITH OSTEOPOROSIS AND OSTEOPOROTIC FRACTURES DURING THERAPY WITH RECOMBINANT ERYTHROPOIETIN, ROSUVASTATIN AND THEIR COMBINATIONS

  The experiment was carried out in female white Wistar rats. The effects of recombinant erythropoietin, rosuvastatin and their combination were ...

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• LIPID DISTRESS-SYNDROME AND PROSPECTS OF ITS CORRECTION BY STATINES

  Endothelial dysfunction in peritonitis: The formed concept of lipid distress syndrome (LDS) allows us to develop a working hypothesis ...

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• EVALUATION OF PHARMACOLOGICAL CORRECTION OF L-NAME-INDUCED ENDOTHELIAL DYSFUNCTION, PLATELET AGGREGATION AND VENOUS TONE WITH DIOSMIN DETRALEX 1000 MG

  Introduction. Chronic venous diseases are one of the urgent problems of modern medicine. Recent studies have shown high significance of endothelial ...

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• FRACTALKINE AND ASYMMETRIC DIMETHYLARGININE LEVELS IN PATIENTS WITH CORONARY ARTERY DISEASE DEPENDING ON THE PRESENCE OF TYPE 2 DIABETES MELLITUS AND THE CHARACTER OF CORONARY ARTERIES LESIONS

  The purpose of the research is to assess the fractalkine and asymmetric dimethylarginine (АDМА) levels in patients with coronary artery ...

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• DIASTOLIC DYSFUNCTION OF MYOCARDIUM IN PATIENTS WIHT CHRONIC CARDIAC INSUFFICIENCY OF DIFFERENT GENESIS

  The article covers the results of studies of the diastolic dysfunction of the left ventricular myocardium in patients with chronic ...

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• NEW APPROACHES OF MORFOFUNKTIONAL PHARMACOLOGICAL CORRECTION OF VIOLATIONS OF CARDIOVASCULAR SYSTEM IN EXPERIMENTAL PREECLAMPSIA

  Experimental Modeling ADMA-like preeclampsia administration to rats was performed by N-nitro-L-arginine methyl ester, from 14 to 20 days of pregnancy. ...

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• METHOD OF CORRECTION OF ENDOTHELIAL DYSFUNCTION WITH COMBINATION OF ADEMETIONINE AND TAURINE

  Abstract. In the experiment, was made a simulation of endothelial dysfunction in male rats of Wistar-line byintraperitoneal administration of L-NAME ...

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• NUCLEAR FACTOR KAPPA B AS A POTENTIAL TARGET FOR PHARMACOLOGICAL CORRECTION ENDOTHELIUM-ASSOCIATED PATHOLOGY

  The nuclear factor kappa B (NF-κB) is one of transcription factors. A high interest in studying the biological role ...

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• THE ETIOLOGY AND PATHOGENESIS OF ATHEROSCLEROSIS: MODERN INSIGHTS AND AGE-DEPENDENT ASPECTS (REVIEW)
   

  Background: Atherosclerosis is a leading cause of morbidity and mortality worldwide. It is a systemic pathological process attributed ...

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• COMPREHENSIVE ASSESSMENT OF USING MICRONISED PURIFIED FLAVONOID FRACTION IN THE CORRECTION OF DISORDERS ASSOCIATED WITH ADMA-LIKE PREECLAMPSIA IN EXPERIMENT
   

  Background: About 10% of pregnancies in the world are accompanied by hypertensive disorders, while from 2 to 8% are preeclampsia. ...

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• COEXISTENCE OF URINARY INCONTINENCE AND OSTEOPOROSIS IN FEMALES – A SYSTEMATIC REVIEW

  Background: Urinary incontinence (UI) is described as the involuntary leakage of urine and is a global problem. The younger ...

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  This paper deals with the study of endothelio- and cardioprotective activity of arginase II selective inhibitor, the substance under the ...

  Abstract | Full text (PDF)

• STUDY OF THE EFFECT OF SELECTIVE INHIBITOR OF ARGINASE II KUD 975 AND OF LOW DOSES OF ACETYLSALICYLIC ACID ON THE FUNCTIONAL PARAMETERS OF THE CARDIOVASCULAR SYSTEM IN EXPERIMENTAL PREECLAMPSIA

  Introduction: Over the past decade, preeclampsia has been the subject of an increased attention, as this complication is the most ...

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• PREVALENCE AND INTENSITY OF AUTONOMIC DYSFUNCTION AMONG YOUNG ATHLETES

  High physical activity and lifestyle factors lead to dysfunction of the autonomic nervous system in athletes. The author examines the ...

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• COGNITIVE DYSFUNCTION IN ELDERLY PATIENTS WITH CHRONIC SYSTOLIC HEART FAILURE
   

  Background: Nowadays, we can see a rapid increase in systolic chronic heart failure patients. Cognitive decline is one ...

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• CORRECTION OF ADMA-INDUCED PREECLAMPSIA WITH THE USE OF PHOSPHODIESTERASE 5 AND SELECTIVE INHIBITOR OF ARGINASE II ZB49-0010

  Simulation experimental ADMA-like preeclampsia was carried out by administering the rats with L-NAME during 14-20 days of pregnancy. In animals, ...

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• CORRECTION OF MITOCHONDRIAL DYSFUNCTION WITH CINNAMIC ACIDS IN EXPERIMENTAL HYPERCYTOKINEMIA

  Background: Mitochondrial dysfunction is an essential component of the hypercytokine neurotoxicity pathogenesis and is a promising pharmacotherapeutic target. The ...

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• USE OF SELECTIVE INHIBITORS OF ARGINASE 2 AND TADALAFIL IN COMBINED COMPENSATION OF HOMOCYSTEINE-INDUCED ENDOTHELIAL DYSFUNCTION

  Use of selective inhibitors of arginase 2 in combination with tadalafil on in the course of modeling of homocysteine-induced endothelial ...

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• THE STUDY OF THE ENDOTHELIAL PROTECTIVE PROPERTIES OF THE L-NORVALINE COMBINATION WITH MEXIDOL IN THE SIMULATION OF L-NAME-INDUCED NO DEFICIENCY

  Introduction: The endothelium is considered as a target for the prevention and treatment of pathological processes leading to cardiovascular diseases.

  ...

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• NEUROPROTECTIVE EFFECT OF L-CARNITINE. FOCUS ON CHANGING MITOCHONDRIAL FUNCTION
   

  Introduction: In this study, the neuroprotective effect of L-carnitine administered per os in a dose of 25 mg/kg – ...

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• IMIDAZOLINE RECEPTORS AGONISTS: POSSIBLE MECHANISMS OF ENDOTHELIOPROTECTION

  Imidazoline receptor agonists are one of the groups of contemporary antihypertensive drugs with the pleiotropic cardiovascular effects. In ...

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• SUDYING THE DYSFUNCTION OF PERSONNEL UNITS IN THE MANAGEMENT SYSTEM OF MODERN PRINT MEDIA

  The paper describes a detailed study of two forms of dysfunction of personnel units of the management system. The ...

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• MARKETING ANALYSIS OF THE MARKET OF MEDICINES USED IN THE TREATMENT OF DYSTONIA IN CHILDREN

  The authors conducted a market research of the Russian market of medicinal preparations used in the therapy of vegetovascular dystonia. ...

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• PULSE PRESSURE AS A PREDICTOR OF THE DEVELOPMENT OF HYPERTENSION

  Samples with exercise stress include bicycle ergometry (BEM) used due to its simplicity and diagnostic value. BEM provides important information ...

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• UBIQUINOL AMELIORATES ENDOTHELIAL DYSFUNCTION AND INCREASES EXPRESSION OF MIRNA-34A IN A RAT MODEL OF PULMONARY HYPERTENSION

  Introduction: In this research, we evaluate the effect of intravenously administrated solubilized ubiquinol on 4-week monocrotalin-induced pulmonary hypertension ...

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• THE EFFECT OF NEW FORMS FOR EXTERNAL APPLICATION ON THE VASODILATING FUNCTION OF THE ENDOTHELIUM AND THE CONCENTRATION OF ENDOTHELIAL NITRIC OXIDE SYNTHASES IN RATS WITH AN EXPERIMENTAL MODEL OF A PATHOLOGICAL SCAR AT EARLY HEALING TIMES

  Introduction: According to statistical data, the tendency towards an increase in the number of patients with keloid and hypertrophic ...

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• CORRECTION OF MORPHOFUNCTIONAL DISORDERS WITH ASIALOERYTHROPOIETIN AND SELECTIVE INHIBITOR OF ARGINASE II KUD975 IN CASES OF ISCHEMIC KIDNEY DAMAGE IN THE EXPERIMENT

  Introduction: Acute kidney injury (AKI), which is based on ischemic-reperfusion damage, is a widespread life-threatening condition and remains a serious ...

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• PRECLINICAL STUDY OF INNOVATIVE PEPTIDES MIMICKING THE SPACE STRUCTURE OF THE Α-HELIX B OF ERYTHROPOIETIN
   

  Introduction: The aim of this study was to examine the effectiveness of innovative peptides obtained by addition of polypeptide motifs ...

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• SEARCH FOR NEW PHARMACOLOGICAL TARGETS FOR INCREASING THE EFFICIENCY OF CORRECTION OF CARDIOVASCULAR DISEASES

  Introduction: Cardiovascular disease (CVD) is the leading cause of death worldwide: no other reason causes as many deaths a year ...

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• ENDOTHELIOPROTECTIVE PROPERTY OF THE COMBINATION OF THE THIOCTIC ACID AND ROSUVASTATIN SHOWN IN THE ENDOTHELIAL DYSFUNCTION MODELS

  During the experiment, the modeling of endothelial dysfunction of male rats was performed by intraperitoneal administration of L-NAME at a ...

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• PHARMACOLOGICAL CORRECTION OF EXPERIMENTAL OSTEOPOROSIS AND FRACTURES RELATED TO IT BY MEANS OF ROSUVASTATIN, L-NORVALINE AND THEIR COMBINATION

  Introduction: osteoporosis (OP) is a multifactorial disease which is based on a dynamic decrease in bone mass and, as a ...

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• ROLE OF ARGINASE 2 AS A POTENTIAL PHARMACOLOGICAL TARGET FOR THE CREATION OF NEW DRUGS TO CORRECT CARDIOVASCULAR DISEASES
   

  Introduction: The review provides relevant information about arginase 2, the role of this enzyme in the formation of endothelial dysfunction ...

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• ENDOTHELIO- AND CARDIOPROTECTIVE EFFECTS OF VITAMIN В6 AND FOLIC ACID IN MODELLING METHIONINE-INDUCED HYPERHOMOCYSTEINEMIA

  The endotelio- and cardioprotective effects of vitamin B6 (2 mg/kg) and folic acid (0.2 mg/kg) upon modeling of methionine-induced hyperhomocysteinemia ...

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• INTERLEUKIN-6 IS A POTENTIAL TARGET FOR A CORRECTION OF ENDOTHELIAL DYSFUNCTION ASSOCIATED WITH LOW-GRADE SYSTEMIC INFLAMMATION

  Introduction: One of pathogenetic links of development of endothelial dysfunction, as an early marker of cardiovascular disease and comorbidity, ...

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• DYSFUNCTIONS OF YOUTH POLICY DESIGN IN RUSSIAN UNIVERSITIES
  (USING THE EXAMPLE OF THE PARTICIPANTS OF THE PRIORITY 2030 PROGRAM) 

  The article analyzes the models of youth policy presented in the development programs of universities participating in the Priority 2030 ...

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• ENDOTHELIAL DYSFUNCTION: COMPARATIVE EVALUATION OF ULTRASOUND DOPPLEROGRAPHY, LASER DOPPLERFLOWMETRY AND DIRECT MONITORING OF ARTERIAL PRESSURE FOR CONDUCTING PHARMACOLOGICAL TESTS IN RATS

  Introduction: The importance of the problem of endothelial dysfunction makes it essential to improve approaches to its evaluation. Due ...

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• STUDY OF THE INFLUENCE OF L-NORVALINE, ROSUVASTATIN AND THEIR COMBINATION ON THE LEVEL OF MICROCIRCULATION IN BONE TISSUE IN EXPERIMENTAL OSTEOPOROSIS AND FRACTURES ON ITS BACKGROUND

  The experiment was carried out in female white Wistar rats to investigate the effect of L-norvaline, rosuvastatin and their combination ...

  Abstract | Full text (PDF)